240g Pseudokatalase "PC-KUS" Creme für Vitiligo

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Verkäufer: joelasix ✉️ (507) 100%, Artikelstandort: Miami, Florida, US, Versand nach: WORLDWIDE, Artikelnummer: 112762260354 240g Pseudokatalase "PC-KUS" Creme für Vitiligo.

WHAT IS VITILIGO?

 

Vitiligo is a disorder in which white patches of skin appear on

different parts of the body. This happens because the cells that make pigment

(color) in the skin are destroyed. These cells are called melanocytes. Vitiligo can also affect the mucous membranes (such as the tissue inside the mouth and nose) and the eye.

 

WHAT CAUSES VITILIGO?

 

Vitiligo occurs when melanin-forming cells (melanocytes) die or stop producing melanin — the pigment that gives your skin, hair and eyes color. The involved patches of skin become lighter or white. Doctors don't know why the cells fail or die. Therefore, the cause is not clearly known. 

 

It may be related to:

·       A disorder in which your immune system attacks and destroys the melanocytes in the skin

·       Family history (heredity)

·       A trigger event, such as sunburn, stress or exposure to industrial chemicals

 

WHO IS AFFECTED BY VITILIGO?

 

Many people develop it in their twenties, but it can occur at any age. The disorder

affects all races and both sexes equally, however, it is more noticeable in people

with dark skin. People with certain autoimmune diseases (such as hyperthyroidism) are more likely to get vitiligo than people who don't have any autoimmune diseases.

Scientists do not know why vitiligo is connected with these diseases. However,

most people with vitiligo have no other autoimmune disease. Vitiligo may also run in families. Children whose parents have the disorder are more likely to develop vitiligo. However, most children will not get vitiligo even if a parent has it.

 

WHAT ARE THE SYMPTOMS OF VITILIGO?

 

White patches on the skin are the main sign of vitiligo. These patches are more

common in areas where the skin is exposed to the sun. The patches may be on the

hands, feet, arms, face, and lips. Other common areas for white patches are:

 

 The armpits and groin (where the leg meets the body)

 Around the mouth

 Eyes

 Nostrils

 Navel

 Genitals

 Rectal areas

 

People with vitiligo often have hair that turns gray early. Those with dark skin may notice a loss of color inside their mouths.

 

WILL THE WHITE PATCHES SPREAD?

 

There is no way to tell if vitiligo will spread. For some people, the white patches do not spread. But often the white patches will spread to other areas of the body. For some people, vitiligo spreads slowly, over many years. For other people, spreading occurs quickly. Some people have reported more white patches after physical or emotional stress.

 

COMPLICATIONS

 

People with vitiligo may be at increased risk of:

·       Social or psychological distress

·       Sunburn and skin cancer

·       Eye problems, such as inflammation of the iris (iritis)

·       Hearing loss

 

PSEUDOCATALASE PC-KUS TREATMENT

 

Pseudocatalase  PC-KUS has recently become a gold standard for patients suffering from vitiligo.  Pseudocatalase improves the appearance by restoring the pigmentation in the affected areas. Though it can take 2-3 months to see results, it drastically improves the quality of life and apperarance. Today with pseudocatalase, vitiligo is a treatable condition. That’s is a breakthrough, considering the recent hopeful treatment options.

 

Dr. Karin U. Schallreuter and her colleagues, a professor of clinical and experimental dermatology at the University of Bradford in West Yorkshire, England, created pseudocatalase PC-KUS. The studies were conducted to apply PSEUDOCATALASE CREAM TWICE DAILY and EXPOSE AREA OF TREATMENT TO THE SUN APPROXIMATELY 15 MINUTES TWICE A WEEK or to a short-term narrow-band of ultraviolet B (UVB) phototherapy.

 

It was shown to lower levels of hydrogen peroxide (H2O2) on the skin, as well as improve defense by supplementing catalase. Catalase, through activation by UV light, will break down H2O2 to oxygen and water, instead of accumulation of H2O2 that consequently affected pigmentation of the skin.

 

YOUR ORDER IS 240 GRAMS OF PSEUDOCATALASE PC-KUS INCLUDING CREAM AND DIRECTION OF USE.

REFERENCED STUDIES

 

Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients.

Schallreuter KU 1 ,  Wood JM ,  Lemke KR ,  Levenig C .

Author information

·       1 Department of Dermatology, University of Hamburg, Germany.

Abstract

Thirty-three patients with the depigmentation disorder vitiligo were successfully treated with a new topical application of pseudocatalase, calcium and short-term UVB light exposure. First repigmentation occurred in the majority of cases after 2-4 months. Complete repigmentation on the face and dorsum of the hands appeared in 90% of the group. In all patients, active depigmentation was arrested. None of them developed new lesions during treatment. No recurrence of the disease was observed during a 2-year follow-up. The rationale for this pilot study originated from a recent understanding of vitiligo at the molecular level. The involved epidermis produces hydrogen peroxide due to defective tetrahydrobiopterin recycling and increased monoamine oxidase A activity, whereupon catalase is inactivated. In addition, calcium homeostasis is perturbed in the affected skin. The substitution for insufficient catalase by a pseudocatalase together with calcium and UVB exposure lead to effective repigmentation.

 

 

Pseudocatalase and Vitiligo

Mark V. Dahl, MD  reviewing  Schallreuter KU et al. Int J Dermatol 2008 Jul.

 

Two thirds of children treated with pseudocatalase PC-KUS achieved 75% improvement or better in their vitiligo.

 

Hydrogen peroxide–mediated lipid peroxidation may damage epidermal cells, causing vitiligo. In cultured melanocytes and keratinocytes, vacuolization caused by peroxidation can be prevented by catalase, which breaks down peroxides, and by “pseudocatalase” (PC-KUS), a complex of bis-Mn III  [EDTA]2  [HCO3 - ]2 , which can be applied to skin and activated by narrow-band ultraviolet-B (NB-UVB) radiation.

 

In this study, 71 children with vitiligo were treated with PC-KUS that was activated by UVB daily. The PC-KUS topical preparation was applied twice daily to the entire body. NB-UVB was administered once daily for 14 days and then twice weekly for 4 weeks. Thereafter, PC-KUS was applied once daily, and up to 1 hour of sun exposure daily was allowed. Ten children received NB-UVB alone (monotherapy). Assessment was made after 12 months.

Progression of vitiligo was halted in 70 of the 71 children treated with NB-UVB–activated PC-KUS; 66 experienced better than 75% repigmentation of the face and neck, and 39% had complete repigmentation. Better than 75% repigmentation also occurred in 48 of 61 treated children with vitiligo on the trunk and in 40 of 55 children with vitiligo on the extremities. Only five children with vitiligo on the hands had 75% repigmentation. Success was independent of Fitzpatrick skin type and disease duration. The 10 children treated with monotherapy did not experience much if any repigmentation, and their disease progression was not halted.

- See more at: http://www.jwatch.org/jd200808150000002/2008/08/15/pseudocatalase-and-vitiligo#sthash.7LD1xyub.dpuf

 

  • Condition: Neu mit Karton
  • Country/Region of Manufacture: United States
  • Brand: Medica

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