Zeitgenössische Drogensynthese von Jie Jack Li (englisch) Hardcover-Buch

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Contemporary Drug Synthesis

by Jie Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth

Drug synthesis comprises the heart of the pharmaceutical business today. Both in early development (identifying and optimizing a lead) as well as in process development (scale-up), the ability to develop elegant and economical synthetic routes proves tantamount to the commercial success of a drug.

FORMAT Hardcover LANGUAGE English CONDITION Brand New

Publisher Description

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen othersProvides an in-depth introduction to each drug, followed by a detailed account of its synthesisOrganizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Back Cover

An integrated and insightful look at successful drug synthesis in today’s drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry’s most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Flap

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Author Biography

JIE-JACK LI, PhD, DOUGLAS S. JOHNSON, PhD, DRAGO R. SLISKOVIC, PhD, AND BRUCE D. ROTH, PhD, are all members of Pfizer Global Research and Development, and are among the most prominent scientists working in drug discovery today.

Table of Contents

Preface v Trade Names and Their Corresponding USANs xi Acronyms and Abbreviations xiii Chapter 1. Antithrombotics: Ticlopidine (Ticlid) and Clopidogrel (Plavix) 1 Chapter 2. Anti-inflammatory Cyclooxygenase-2 Selective Inhibitors: Celecoxib (Celebrex) and Rofecoxib (Vioxx) 11 Chapter 3. H+/K+ -ATPase Inhibitors: Esomeprazole (Nexium) 21 Chapter 4. Protein-tyrosine Kinase Inhibitors: Imatnib (Gleevec) and Gefitinib (Iressa) 29 Chapter 5. Non-sedating Antihistamines 39 Chapter 6. Cosmeceuticals: Istretinoin (Accutane), Tazarotene (Tazorac), Minoxidil (Rogaine), and Finasteride (Propecia) 55 Chapter 7. Antibacterials: Ciprofloxacin (Cipro) and Linezolid (Zyvox) 75 Chapter 8. Atypical Antupsychotics 89 Chapter 9. Atovastatin Calcium (Lipitor) 113 Chapter 10. Antidepressants 125 Chapter 11. Anti-obesity: Orlistat (Xenical) 149 Chapter 12. Triptans for Migrane 161 Chapter 13. PDE 5 Inhibitors for Erectile Dysfunction: Sildenafil (Viagra), Vardenafil (Levitra), and Tadalafil (Cialis) 189 Chapter 14. Antiasthmatics 201 Index 214

Review

"…the authors have made an excellent selection of drugs and the coverage of the synthetic chemistry employed in their production is exemplary…" (Chemistry & Industry, 5th September 2005) "…a clear and easy to use reference for anyone working in drug discovery and development." (E-STREAMS, January 2005) "...a very useful book...for...pharmaceutical industry scientists...[and] the larger medicinal and organic chemistry community..." (Journal of Medicinal Chemistry, November 18, 2004) "…an outstanding primer on methods for chemical drug synthesis…the test is most useful, well written, and serves as a useful read for those interested in drug synthesis." (American Journal of Therapeutics, September/October 2004) "…highly interesting…keeps to the facts…" (www.organische-chemie.ch) '…I warmly recommend this book to synthetic organic chemists both in industry and in academia.' (Organic Process Research and Development Journal, July 2007)

Long Description

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Review Text

??the authors have made an excellent selection of drugs and the coverage of the synthetic chemistry employed in their production is exemplary?? (Chemistry & Industry, 5th September 2005) "?a clear and easy to use reference for anyone working in drug discovery and development." (E-STREAMS, January 2005) "...a very useful book...for...pharmaceutical industry scientists...[and] the larger medicinal and organic chemistry community..." (Journal of Medicinal Chemistry, November 18, 2004) "?an outstanding primer on methods for chemical drug synthesis?the test is most useful, well written, and serves as a useful read for those interested in drug synthesis." (American Journal of Therapeutics, September/October 2004) ??highly interesting?keeps to the facts?? (www.organische-chemie.ch) ??I warmly recommend this book to synthetic organic chemists both in industry and in academia.' (Organic Process Research and Development Journal, July 2007)

Review Quote

"...the authors have made an excellent selection of drugs and the coverage of the synthetic chemistry employed in their production is exemplary..." ( Chemistry & Industry , 5 th September 2005) "...a clear and easy to use reference for anyone working in drug discovery and development." ( E-STREAMS , January 2005) "...a very useful book...for...pharmaceutical industry scientists...[and] the larger medicinal and organic chemistry community..." ( Journal of Medicinal Chemistry , November 18, 2004) "...an outstanding primer on methods for chemical drug synthesis...the test is most useful, well written, and serves as a useful read for those interested in drug synthesis." ( American Journal of Therapeutics , September/October 2004) "...highly interesting...keeps to the facts..." ( www.organische-chemie.ch ) '...I warmly recommend this book to synthetic organic chemists both in industry and in academia.' ( Organic Process Research and Development Journal , July 2007)

Feature

An integrated biological and chemistry text on drug synthesis for the drug discovery market Authored by three prominent scientists in the pharmaceutical industry, the coverage spans various corporations and includes coverage of more than 100 drugs. Organized by therapeutic areas, the contents include synthetic strategies and basic principles, as illustrated by real-world examples of prominent drugs, including Lipitor, Celebrex, Vioxx, Viagra, Relenza, Prilosec, and many others. Highlights both medicinal and process synthetic routes. Appropriate for graduate-level courses in medicinal chemistry

Details ISBN0471214809 Author Bruce D. Roth Short Title CONTEMP DRUG SYNTHESIS Language English ISBN-10 0471214809 ISBN-13 9780471214809 Media Book Format Hardcover Illustrations Yes Year 2004 Place of Publication New York Country of Publication United States Alternative 9780471686743 Edition 1st Series Wiley Series on Drug Synthesis DOI 10.1604/9780471214809 UK Release Date 2004-07-13 AU Release Date 2004-06-11 NZ Release Date 2004-06-11 Pages 240 Publisher John Wiley & Sons Inc Publication Date 2004-07-13 Imprint Wiley-Interscience DEWEY 615.19 Audience Professional & Vocational US Release Date 2004-07-13

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  • Condition: Neu
  • ISBN-13: 9780471214809
  • Book Title: Contemporary Drug Synthesis
  • ISBN: 9780471214809
  • Publication Year: 2004
  • Type: Textbook
  • Format: Hardcover
  • Subject Area: Chemical Engineering
  • Language: English
  • Publication Name: Contemporary Drug Synthesis
  • Item Height: 259mm
  • Author: Jie Jack Li, Bruce D. Roth, Drago R. Sliskovic, Douglas S. Johnson
  • Publisher: John Wiley & Sons INC International Concepts
  • Item Width: 198mm
  • Item Weight: 656g
  • Number of Pages: 240 Pages

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