Weitere Radiopharmazeutika für die Positronenemissionstomographie und neue Strategien

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Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production, Volume 2

by Peter J.H. Scott, Michael R. Kilbourn

This book provides reliable methods, including information to duplicate procedures, for synthesizing radiopharmaceuticals used in positron emission tomography (PET) imaging and saves chemists time by eliminating the time-consuming process of searching journal articles and extracting details from lengthy experimental sections.

FORMAT Hardcover LANGUAGE English CONDITION Brand New

Publisher Description

This book describes methods and procedures for preparing PET radiopharmaceuticals, and highlights new methods for conducting radiochemical reactions with carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in positron emission tomography (PET) imaging.

•    Provides reliable methods for radiochemical syntheses and reactions, including all essential information to duplicate the procedure
•    Eliminates the time-consuming process of searching journal articles and extracting pertinent details from lengthy experimental sections or supporting information
•    Focuses on an emerging and important area for pharmaceutical and medical applications
•    Encompasses technical, regulatory, and application aspects
•    Includes solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control

Back Cover

The ultimate reference guide to the synthesis of radiopharmaceutical The Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory. Volume 2 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today as well as important new methods in radiochemistry. Contributions from leading researchers detail methods and procedures for conducting radiochemical reactions to prepare important radiopharmaceuticals that are used in positron emission tomography (PET) imaging. Also highlighted in this book are new approaches to carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in PET imaging. New methods include solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control. These detailed monographs provide readers the necessary information needed to reproduce these synthetic reactions and new procedures in their own labs. Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals.

Flap

The ultimate reference guide to the synthesis of radiopharmaceutical The Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory. Volume 2 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today as well as important new methods in radiochemistry. Contributions from leading researchers detail methods and procedures for conducting radiochemical reactions to prepare important radiopharmaceuticals that are used in positron emission tomography (PET) imaging. Also highlighted in this book are new approaches to carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in PET imaging. New methods include solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control. These detailed monographs provide readers the necessary information needed to reproduce these synthetic reactions and new procedures in their own labs. Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals.

Author Biography

Peter J. H. Scott is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School (USA), Director of the University of Michigan PET Center (USA) and a member of the Interdepartmental Program in Medicinal Chemistry. Professor Scott edited Linker Strategies in Solid-Phase Organic Synthesis (also from Wiley) and is the series editor for both the Wiley Series on Radiochemical Syntheses and the Wiley Series on Solid Phase Organic Syntheses.

Table of Contents

Contributors xi Editorial Preface xvii Abbreviations xix PART I FLUORINE-18 LABELED RADIOPHARMACEUTICALS 1 1. Synthesis of (−)-[18F]Flubatine ([18F]FLBT) 3
Megan N. Stewart, Brian G. Hockley, and Peter J. H. Scott 2. Synthesis of [18F]-(−)Fluoroethoxy Benzovesamicol ([18F]FEOBV) 13
Brian G. Hockley, Megan N. Stewart, and Peter J. H. Scott 3. Synthesis of [18F]Fluoromethylcholine ([18F]FCH) via [18F]Fluoromethyl Tosylate 21
Melissa E. Rodnick, Allen F. Brooks, Brian G. Hockley, Bradford D. Henderson, and Peter J. H. Scott 4. Radiosynthesis of [18F]Flotegatide ([18F]RGD-K5) 29
Hartmuth C. Kolb, Fanrong Mu, Umesh Gangadharmath, Vani P. Mocharla, Zhihong Zhu, Ashok Chaudhary, and Joseph C. Walsh 5. Synthesis of 3-[18F]Fluoro-5-(2-Pyridinylethynyl) Benzonitrile ([18F]FPEB) 41
Steven H. Liang, Daniel L. Yokell, Raul N. Jackson, Peter A. Rice, Eli Livni, David Alagille, Gilles Tamagnan, Thomas Lee Collier, and Neil Vasdev 6. Radiosynthesis of 2′-Deoxy-2′-[18F]Fluoro-5-Methyl-1-β-d-Arabinofuranosyluracil ([18F]FMAU) 53
Kai Chen and Peter S. Conti PART II CARBON-11 LABELED RADIOPHARMACEUTICALS 63 7. Synthesis of N-[11C]Methyl-4-Piperidinyl Propionate ([11C]PMP) 65
Xia Shao and Peter J. H. Scott 8. Synthesis of 1-(2,4-Dichlorophenyl)-4-Cyano-5-(4-[11C]methoxyphenyl)-N-(Piperidin-1-yl)-1H-Pyrazole-3-Carboxamide ([11C]OMAR) 73
Xia Shao, Keunsam Jang, and Peter J. H. Scott 9. Synthesis of Carbon-11 Labeled (+)-4-Propyl-3,4,4a,5,6,10b-Hexahydro-2H-Naphtho[1,2-b][1,4]Oxazin-9-Ol ([11C]-(+)-PHNO) 81
Christophe Plisson, Joaquim Ramada-Magalhaes, and Jan Passchier 10. Synthesis of (R)-[N-Methyl-11C]PK11195 93
Vítor H. Alves, Antero J. Abrunhosa, and Miguel Castelo-Branco PART III OTHER RADIOPHARMACEUTICALS 103 11. Synthesis of Oxygen-15 Water ([15O]H2O) 105
David W. Dick and G. Leonard Watkins PART IV NEW METHODS FOR THE SYNTHESIS AND QUALITY CONTROL OF RADIOPHARMACEUTICALS 115 12. Direct, Nucleophilic Radiosynthesis of [18F]Trifluoroethyl Tosylate 117
Patrick J. Riss, Waqas Rafique, and Franklin I. Aigbirhio 13. Synthesis of [18F]N-Methyl Lansoprazole via Generation of a [18F]Trifluoromethyl Group 123
Allen F. Brooks, Melissa E. Rodnick, Garret M. Carpenter, and Peter J. H. Scott 14. [18F]Fluorination of (Mesityl)(Aryl)Iodonium Salts 129
Naoko Ichiishi, Allen F. Brooks, Joseph J. Topczewski, Melissa E. Rodnick, Melanie S. Sanford, and Peter J. H. Scott 15. Pd(IV)-Mediated Fluorination of Arenes with [18F]F– for PET Imaging 139
Nathan J. Schauer, Stephen M. Carlin, Hong Ren, and Jacob M. Hooker 16. Silicon Fluoride Acceptors (SIFAs) for Peptide and Protein Labeling with 18F 149
Ralf Schirrmacher, Alexey Kostikov, Carmen Wängler, Klaus Jurkschat, Vadim Bernard-Gauthier, Esther Schirrmacher, and Björn Wängler 17. Solid Phase Synthesis of [18F]-2-Fluoro-2-Deoxy-d-Glucose: A Resin-Linker-Vector (RLV) Approach 163
Lynda J. Brown, Imtiaz Khan, Harry J. Wadsworth, Alexander Jackson, Nianchun Ma, Nicolas Millot, Sue M. Champion, Denis R. Bouvet, Alex M. Gibson, and Richard C. D. Brown 18. Production and Reaction of [11C]Carbon Disulfide for the Synthesis of [11C]Dithiocarbamates 177
Philip W. Miller 19. One-Pot, Direct Incorporation of [11CO2] into Carbamates 185
Christian K. Moseley and Jacob M. Hooker 20. Radiosynthesis of [11C]Carboxamides via Reaction of [11C]CO2 Captured by a Cu(I)-Based Catalyst System with Boronic Acid Ester Precursors 197
Patrick J. Riss, Shuiyu Lu, Sanjay Telu, Franklin I. Aigbirhio, and Victor W. Pike 21. Ethanol as a Solvent for Carbon-11 Radiochemistry 207
Xia Shao, Maria V. Fawaz, Keunsam Jang, and Peter J. H. Scott 22. Synthesis and Applications of [11C]Hydrogen Cyanide 233
Xia Shao, Melissa E. Rodnick, Allen F. Brooks, and Peter J. H. Scott 23. Determination of Radiochemical Purity and Radiochemical Identity of [13N]NH3 Using Thin Layer Chromatography 241
Peter A. Rice and Daniel L. Yokell Appendix 1: Supplier Information 247 Index 253

Long Description

The ultimate reference guide to the synthesis of radiopharmaceutical The Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory. Volume 2 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today as well as important new methods in radiochemistry. Contributions from leading researchers detail methods and procedures for conducting radiochemical reactions to prepare important radiopharmaceuticals that are used in positron emission tomography (PET) imaging. Also highlighted in this book are new approaches to carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in PET imaging. New methods include solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control. These detailed monographs provide readers the necessary information needed to reproduce these synthetic reactions and new procedures in their own labs. Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals.

Details ISBN1118237846 Series Wiley Series on Radiochemical Syntheses ISBN-10 1118237846 ISBN-13 9781118237847 Format Hardcover Year 2015 Edition 1st Subtitle Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production Edition Description Volume 2 Language English Media Book Series Number 2 Place of Publication New York Country of Publication United States Pages 288 Edited by Peter J. H. Scott Short Title RADIOCHEMICAL SYNTHESES V02 V0 UK Release Date 2015-06-08 AU Release Date 2015-06-15 NZ Release Date 2015-06-15 Author Michael R. Kilbourn Publisher John Wiley & Sons Inc Publication Date 2015-06-08 Imprint John Wiley & Sons Inc DEWEY 616.07575 Audience Professional & Vocational US Release Date 2015-06-08

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  • Condition: Neu
  • ISBN-13: 9781118237847
  • Book Title: Further Radiopharmaceuticals for Positron Emission Tomography and
  • ISBN: 9781118237847
  • Publication Year: 2015
  • Type: Textbook
  • Format: Hardcover
  • Language: English
  • Publication Name: Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production
  • Item Height: 233mm
  • Author: Peter J. H. Scott
  • Publisher: John Wiley & Sons INC International Concepts
  • Item Width: 162mm
  • Subject: Medicine, Radiology
  • Item Weight: 544g
  • Number of Pages: 288 Pages

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